Every baby born a decade from now will have its genetic code mapped at birth, a genome sequencing company has predicted.
A complete DNA read-out for every newborn will be technically feasible and affordable in less than five years, promising a revolution in healthcare, says the chief executive of Illumina.
This will open a new approach to medicine, by which conditions such as diabetes and heart disease can be predicted and drugs prescribed more safely and effectively.
The development, however, will raise difficult questions about privacy and access to individuals’ genetic records. Many people may be reluctant to have their genome read, for fear that the results could be used against them by an employer or insurance company.
The prospect of genome screening for all has emerged because of the plummeting cost of the relevant technology.
The Human Genome Project, which published its first rough sequence of mankind’s genetic code in 2001, cost an estimated $4 billion. By the time the scientists James Watson and Craig Venter had their genomes mapped two years ago, the cost had fallen to about $1 m.
Last month, Illumina announced a deal with a British company that is developing a new approach to sequencing that could bring costs down further. In an interview with The Times, Dr. Flatley said a genome sequence should be available for less than $1,000 in three to four years.
“The limitations are sociological; when and where people think it can be applied, the concerns people have about misinformation and the background ethics questions.”
“I think those are actually going to be the limits that push it out to a ten-year timeframe,” he added.
By examining which genetic variants a person has inherited, it is possible to identify raised risks of developing an array of conditions, including cardiovascular disease and many cancers. Those at high risk can then be screened more regularly, or given drugs or dietary advice to lower their chances of becoming ill.
Personal genome sequencing, however, will raise legitimate concerns about privacy, “Bad things can be done with the genome. It could predict something about someone—and you could potentially hand information to their employer or their insurance company,” said Dr. Flatley, “Legislation has to be passed.”
Complete genetic privacy, however, was unlikely to be possible, he added.
“People have to recognize that this horse is out of the barn, and that your genome probably can’t be protected, because everywhere you go you leave your genome behind.”
As the benefits become clearer, however, he believes that most people will want their genomes read and interpreted. The apparent benefits would soon eclipse the hazards.
26. A complete DNA read-out is possible in the near future because ______.
27. When will genome screening be actually applied to public, according to Dr. Flatley?
28. The underlined word “conditions” in the text most probably means ______.
29. What might be the “bad thing” associated with personal genome sequencing?
30. What does Dr. Flatley think about genome screening?
问题1选项
A.laws will allow it
B.it will cost less
C.employers will welcome it
D.it is a revolution in healthcare
问题2选项
A.In two or three years.
B.In five-year time.
C.In about ten years.
D.In three or four years.
问题3选项
A.events
B.limitations
C.diseases
D.situations
问题4选项
A.Disclosing a company’s secrets.
B.Predicting a person’s character.
C.Developing cardiovascular disease.
D.Violating a person’s privacy.
问题5选项
A.Its advantages are more than disadvantages.
B.It benefits babies who are at high risks of diseases.
C.It will do harm to people’s privacy.
D.It will help employers choose good candidates.
第1题:B
第2题:C
第3题:C
第4题:D
第5题:A
26.【选项释义】
26. A complete DNA read-out is possible in the near future because ______. 26. 完整的DNA读取在不久的将来是可能的,因为______。
A. laws will allow it A. 法律允许这样做
B. it will cost less B. 它将花费更少
C. employers will welcome it C. 雇主会欢迎它
D. it is a revolution in healthcare D. 这是医疗保健的一场革命
【考查点】事实细节题。
【解题思路】根据题干定位至第二段“在不到五年的时间里,为每个新生儿读取完整的DNA在技术上是可行的,也将是负担得起的(affordable),这预示着医疗保健领域的一场革命(a revolution in healthcare)”,从affordable一词可知,完整的DNA读取在不久的将来是可能的是因为公众能够负担得起。故选择B项正确。
【干扰项排除】
A、C选项没有提到,属于无中生有;
D选项并不是其原因,而是其性质,该项属于出处错位。
27.【选项释义】
27. When will genome screening be actually applied to public, according to Dr. Flatley? 27. 根据弗拉特利博士,基因组筛查何时才能真正应用于公众?
A. In two or three years. A. 两三年内。
B. In five-year time. B. 五年内。
C. In about ten years. C. 大约十年内。
D. In three or four years. D. 三四年内。
【考查点】事实细节题。
【解题思路】文章第七段提到“在三到四年内,一个基因组序列将以低于1000美元的价格面世”,可知,三到四年内基因组筛查就可以应用于公众;然而根据第九段“我认为这些实际上(actually)是将它推到十年期限的限制”,其中“限制”指的是第八段提到的“人们对错误信息的担忧以及背景伦理问题”,从中可知,因为一些社会限制,基因组筛查将推迟到十年的期限,其中原文中的actually一词正好与题干相对应。因此,该题选择C项正确。
【干扰项排除】
A选项没有提到,属于无中生有;
B选项定位到原文第二段“Illumina首席执行官表示(says the chief executive of Illumina),在不到五年的时间里(in less than five years),为每个新生儿进行完整的DNA读取在技术上是可行的,而且是可以负担得起的,有望在医疗保健领域掀起一场革命”可知五年内的这一时间观点是Illumina首席执行官所认为的内容,不是题干所问弗拉特利博士的观点,属于张冠李戴;
D选项并不是实际上能够应用于公众的时间,属于曲解原文。
28.【选项释义】
28. The underlined word “conditions” in the text most probably means ______. 28. 文中下划线的“conditions”很可能是______的意思。
A. events A. 事件
B. limitations B. 限制
C. diseases C. 疾病
D. situations D. 状况,情境
【考查点】词义推理题。
【解题思路】根据conditions定位至倒数第五段第一句“通过检查一个人遗传了哪些基因变异,有可能确定一系列conditions的风险增加,包括(including)心血管疾病和许多癌症”,由including可知,心血管疾病和许多癌症是包括在conditions之内的,而心血管疾病和许多癌症属于疾病,所以推测conditions在这里是指“疾病”的意思。因此,该题选择C项正确。
【干扰项排除】A、B、D选项不符合原文,属于曲解原文。
29.【选项释义】
29. What might be the “bad thing” associated with personal genome sequencing? 29. 与个人基因组测序相关的“坏事”可能是什么?
A. Disclosing a company’s secrets. A. 泄露公司秘密。
B. Predicting a person’s character. B. 预测一个人的性格。
C. Developing cardiovascular disease. C. 心血管疾病的发展。
D. Violating a person’s privacy. D. 侵犯他人隐私。
【考查点】推理判断题。
【解题思路】根据bad thing定位至倒数第四段第一句“然而,个人基因组测序将引起对隐私(privacy)的合理担忧,基因组可以做‘坏事’”,结合第二句“它可以预测一个人的一些事情,你可能会把信息交给他们的雇主或保险公司”,可知,“坏事”是指基因组可以预测一个人的一些事情,并且这些信息将会被卖给雇主或保险公司,这些信息属于个人隐私,所以“bad thing”指的是侵犯个人隐私。因此,该题选择D项正确。
【干扰项排除】
A选项没提到,属于无中生有;
B、C选项不够全面,属于以偏概全。
30.【选项释义】
30. What does Dr. Flatley think about genome screening? 30. 弗拉特利博士如何看待基因组筛查?
A. Its advantages are more than disadvantages. A. 它的优点多于缺点。
B. It benefits babies who are at high risks of diseases. B. 它对那些疾病风险高的婴儿有益。
C. It will do harm to people’s privacy. C. 它会损害人们的隐私。
D. It will help employers choose good candidates. D. 它将帮助雇主选择优秀的候选人。
【考查点】推理判断题。
【解题思路】根据文章最后一段“然而,他相信,随着好处越来越明显,大多数人会希望自己的基因组被解读和解释。显而易见的好处很快就会盖过(eclipse)危险。”可知,尽管基因组筛查会带来隐私泄露的危险,但是它的好处很快就会盖过它的坏处,A项符合题意。
【干扰项排除】
B、D选项没有提到,属于无中生有;
C选项虽然有提到,但是并不全面,属于以偏概全。