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There is ambition and there is Silicon Valley ambition. For where else on a map could a pin be placed when asked to guess where billionaire philanthropists had declared their intention to cure, prevent or manage all human disease before the end of the century?
It was clear from the start that the announcement from Priscilla Chan and her husband, Mark Zuckerberg, nudged at the boundaries of belief. Writing in praise in the US journal, Science, David Baltimore, a Nobel laureate at California Institute of Technology concedes the goal “may raise eyebrows”. Even Cori Bargmann, the renowned neurobiologist who will lead the charge, is aware how it might be perceived. It is “ambitious”, she says, “but not completely ridiculous”.
It is tempting to dismiss the Chan Zuckerberg Initiative as hubris. But the best part of a century is a long time in medicine. Most babies born in 1900 did not live to see the age of 50. Medicine has not been the only reason for the dramatic rise in life expectancy since, but it was a crucial factor. “By 2100 we’ll be shocked by how much we’ve achieved, and we’ll be more shocked with initiatives like this,” says Jim Smith, chief of strategy at the UK’s Medical Research Council.
If not hubris, then what about one-upmanship? Bill Gates wants to eradicate malaria in a generation. Elon Musk wants a Mars colony in a decade. Yuri Milner has set his sights on sending a spacecraft to a star at one-fifth the speed of light. How better to leave your mark higher on the wall than to make every human disease obsolete within your child’s lifetime? Or at least find a way to manage awful conditions, so they no longer mar people’s lives?
But audacious goals are precisely what are needed. “We have to be bold about the scale of the challenge we face in improving human health,” says Steve Caddick, professor of chemical biology at University College London and director of innovation at the Wellcome Trust, the world’s largest biomedical research charity. “What is truly important about this kind of approach is that it creates the hope you need to go from exploratory science to making the world a better place.” He goes on: “Aspiration is essential. This idea that if we put our minds to it, almost anything is possible—that is what can sustain people through the peaks and troughs of decades of research.”

42. .The underlined sentence in Paragraph 1 means that Silicon Valley entrepreneurs ( ).
43. .According to Cori Bargmann and David Baltimore, the Zuckerbergs’ project may be ( ).
44. .In Paragraph 3, the author emphasizes that ( ).
45. .In Paragraph 4, the author implies that ________ ( )can leave the highest mark on the wall.
46. .In Paragraph 5, “peaks and troughs” most likely means ( ).
47. Which of the following is the best title for the passage?

问题1选项
A.aim to achieve a lot more compared with their peers
B.have the ability to cure all diseases of the human race
C.control the most sophisticated technologies in the world
D.have equally ambitious visions compared with their peers
问题2选项
A.delightful to others
B.detrimental to humanity
C.crucial to disease prevention
D.too difficult for others to believe
问题3选项
A.medical research is needlessly time-consuming
B.medical research is crucial to raising life expectancy
C.research in other fields is not as important as medicine
D.people will be shocked by the ineffectiveness of medicine
问题4选项
A.Bill Gates
B.Elon Musk
C.Yuri Milner
D.Mark Zuckerberg
问题5选项
A.“dos and don’ts”
B.“pros and cons”
C.“ups and downs”
D.“nuts and bolts”
问题6选项
A.Raising Life Expectancy
B.Billionaire Philanthropists
C.Cure All Diseases?—Brilliantly Bold
D.Ridiculous Ambition—The Chan Zuckerberg Plan
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